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KMID : 0352720100340030219
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Journal of Ginseng Research
2010 Volume.34 No. 3 p.219 ~ p.226
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Dosage and Duration Effects of Korean Red Ginseng Intake on Frequency of Gross Deletions in the nef Gene
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Choi Young-Keol
Jung You-Sung
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Abstract
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In the present study, we investigated whether a gross deletion in the nef gene (g?nef) is induced by Korean red ginseng (KRG) intake. Ten patients were treated with KRG powder for 3 years in the absence of antiretroviral drug therapy. On average, 3,555 ± 1,042 g KRG was administered per person over 36.1±2.4 months. There was a mild decrease in CD4 T cell count (75 ± 110/mL) over the 36.1±2.4 months (p = 0.059). We obtained 355 nef amplicons using 71 peripheral blood mononuclear cell samples over a 3?year period. All ten patients exhibited g?nef (range, 3.2 to 45.9%). At baseline, 3 of 78 amplicons (3.8%) exhibited g?nef, whereas 18.8% (52/277) revealed g?nef during KRG?intake (p < 0.001). The proportion of g?nef was significantly correlated with monthly dose of KRG (r = 0.89, p < 0.001). The median time for first detection of g?nef was 13 months. In conclusion, our data show that g?nef is inducible by KRG intake and its proportion is dependent on the duration of KRG intake and dose of KRG.
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KEYWORD
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AIDS, HIV?1, nef, Korean red ginseng, Gross deletion
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